Dofetilide and Lumefantrine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lumefantrine
No brand names on recordDofetilide
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Avoid coadministration of artemether/lumefantrine with drugs that prolong the QT interval, including dofetilide, due to the potential for additive effects on QT interval prolongation2. Coadministration of drugs that prolong the QT interval with dofetilide has not been studied and is not recommended 1. If concomitant administration with artemether/lumefantrine and dofetilide is medically required, use caution and consider ECG monitoring. Additionally, caution is advised when administering drugs that prolong the QT interval after completing artemether/lumefantrine therapy, due to the long half-life of lumefantrine (3 to 6 days) 2.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
1 report — tap to read
a) Coadministration of drugs that prolong the QT interval with dofetilide has not been studied and is not recommended 1.
Common questions
Can I take Dofetilide and Lumefantrine together?
An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dofetilide and Lumefantrine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Dofetilide or Lumefantrine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: TIKOSYN(R) oral capsules, dofetilide oral capsules. Pfizer Labs (per manufacturer), New York, NY, 2011. DailyMed
- Product Information: COARTEM® oral tablets, artemether lumefantrine oral tablets. Novartis Pharmaceuticals Corporation (per DailyMed), East Hanover, NJ, 2025. DailyMed
Keep reading about Lumefantrine
Keep reading about Dofetilide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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