Dofetilide

454 interactions 653 cited references
Also sold as: Tikosyn Tikosyn®
About Dofetilide

Dofetilide is an antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or atrial flutter. Read the full Dofetilide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Dofetilide Lurasidone Latuda Increased dofetilide exposure Details Dofetilide Maribavir Livtencity Increased dofetilide exposure Details Dofetilide Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dofetilide Medroxyprogesterone Amen® Increased dofetilide exposure Details Dofetilide Mestranol Increased dofetilide exposure Details Dofetilide Methyclothiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Metolazone An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Nefazodone Increased dofetilide exposure Details Dofetilide Nomegestrol Increased dofetilide exposure Details Dofetilide Norelgestromin Increased dofetilide exposure Details Dofetilide Norethindrone Aygestin Increased dofetilide exposure Details Dofetilide Norgestimate Increased dofetilide exposure Details Dofetilide Norgestrel Increased dofetilide exposure Details Dofetilide Olaparib Lynparza Increased dofetilide exposure Details Dofetilide Paritaprevir Increased dofetilide exposure Details Dofetilide Peppermint Increased dofetilide exposure Details Dofetilide Pibrentasvir Increased dofetilide exposure Details Dofetilide Piperine Increased dofetilide exposure Details Dofetilide Piretanide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Propofol Diprivan Increased dofetilide exposure Details Dofetilide Quinethazone An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Ranitidine Increased dofetilide exposure Details Dofetilide Resveratrol Increased dofetilide exposure Details Dofetilide Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Dofetilide Rimegepant Nurtec Increased dofetilide exposure Details Dofetilide Ropivacaine Additive cardiac effects Details Dofetilide Rucaparib Rubraca Increased dofetilide exposure Details Dofetilide Schizandra Increased dofetilide exposure Details Dofetilide Segesterone Increased dofetilide exposure Details Dofetilide Simeprevir Olysio® Increased dofetilide exposure Details Dofetilide Stiripentol Diacomit Increased dofetilide exposure Details Dofetilide Suvorexant Belsomra Increased dofetilide exposure Details Dofetilide Teriflunomide Aubagio Increased dofetilide exposure Details Dofetilide Ticagrelor Brilinta Increased dofetilide exposure Details Dofetilide Tolvaptan Jynarque Increased dofetilide exposure Details Dofetilide Torsemide Soaanz An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Trichlormethiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Trofinetide Daybue Increased dofetilide exposure Details Dofetilide Troleandomycin Increased dofetilide exposure Details Dofetilide Ulipristal Ella Increased dofetilide exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.