Dofetilide

454 interactions 653 cited references

Also sold as: Tikosyn Tikosyn®

About Dofetilide

Dofetilide is an antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or atrial flutter. Read the full Dofetilide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sulfamethoxazole Cisapride Bictegravir Cimetidine Sparfloxacin Saquinavir

33 Contraindicated 288 Major 131 Moderate 2 Minor

All (454) Contraindicated (33) Major (288) Moderate (131) Minor (2)

Major

Dofetilide Treosulfan Grafapex Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Dofetilide Triclabendazole Egaten An increased risk of QT interval prolongation Details Dofetilide Trifluoperazine An increased risk of QT interval prolongation Details Dofetilide Trilaciclib Increased plasma concentrations of dofetilide Details Dofetilide Trimipramine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Triptorelin Increased risk of QT interval prolongation Details Dofetilide Tucatinib Tukysa Increased exposure to CYP3A substrate and risk of toxicity Details Dofetilide Vandetanib Caprelsa An increased risk of QT interval prolongation and Torsades de pointes Details Dofetilide Vardenafil Levitra An increased risk of QT interval prolongation Details Dofetilide Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Dofetilide Venlafaxine An increased risk of QT interval prolongation Details Dofetilide Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Dofetilide Vilanterol An increased risk of QT interval prolongation Details Dofetilide Vimseltinib Romvimza Increased risk of OCT2 substrate exposure Details Dofetilide Vinflunine Increased risk of QT-interval prolongation Details Dofetilide Voclosporin Lupkynis An increased risk of QT interval prolongation Details Dofetilide Vonoprazan Voquezna Increased CYP3A substrates exposure Details Dofetilide Vorasidenib Voranigo Reduced CYP3A substrate with NTI exposure and reduced efficacy of CYP3A substrate with NTI Details Dofetilide Voriconazole Vfend An increased risk of QT interval prolongation, an increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-re... Details Dofetilide Vorinostat Zolinza An increased risk of QT interval prolongation Details Dofetilide Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Dofetilide Zolmitriptan Zomig An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Zotepine An increased risk of QT prolongation and an increased risk of torsades de pointes Details Dofetilide Zuclopenthixol An increased risk of QT interval prolongation Details Dofetilide Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dofetilide Eribulin Injection Halaven An increased risk of QT interval prolongation Details Dofetilide Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Dofetilide Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Dofetilide Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Dofetilide Granisetron Injection Granisol An increased risk of QT interval prolongation Details Dofetilide Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Dofetilide Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Dofetilide Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Dofetilide Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Dofetilide Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Dofetilide Levofloxacin Injection Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Dofetilide Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.