Dofetilide

Name: Dofetilide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

454 interactions 653 cited references

Also sold as: Tikosyn Tikosyn®

About Dofetilide

Dofetilide is an antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or atrial flutter. Read the full Dofetilide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sulfamethoxazole Cisapride Bictegravir Cimetidine Sparfloxacin Saquinavir

33 Contraindicated 288 Major 131 Moderate 2 Minor

All (454) Contraindicated (33) Major (288) Moderate (131) Minor (2)

Major

Dofetilide Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Dofetilide Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Dofetilide Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Dofetilide Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dofetilide Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Dofetilide Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.