Dofetilide

454 interactions 653 cited references

Also sold as: Tikosyn Tikosyn®

About Dofetilide

Dofetilide is an antiarrhythmic medication used to treat irregular heartbeats like atrial fibrillation or atrial flutter. Read the full Dofetilide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sulfamethoxazole Cisapride Bictegravir Cimetidine Sparfloxacin Saquinavir

33 Contraindicated 288 Major 131 Moderate 2 Minor

All (454) Contraindicated (33) Major (288) Moderate (131) Minor (2)

Major

Dofetilide Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Moderate

Dofetilide Belumosudil Rezurock Increased dofetilide exposure Details Dofetilide Bicalutamide Casodex Increased dofetilide exposure Details Dofetilide Atorvastatin Atorvaliq Increased dofetilide exposure Details Dofetilide Amlodipine Amvaz® Increased dofetilide exposure Details Dofetilide Brodalumab Injection Siliq Increased dofetilide exposure Details Dofetilide Clotrimazole Aardora Anti-Fungal Maximum Strength Increased dofetilide exposure Details Dofetilide Clotrimazole Lozenge Mycelex® Increased dofetilide exposure Details Dofetilide Clotrimazole Topical Cruex Antifungal Increased dofetilide exposure Details Dofetilide Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased dofetilide exposure Details Dofetilide Cyclosporine Injection Atopica Increased dofetilide exposure Details Dofetilide Cyclosporine Ophthalmic Cequa Increased dofetilide exposure Details Dofetilide Alprazolam Xanax Increased dofetilide exposure Details Dofetilide Amprenavir Increased dofetilide exposure Details Dofetilide Aprepitant Aponvie Increased dofetilide exposure Details Dofetilide Bendroflumethiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Benzthiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Berberine Increased dofetilide exposure Details Dofetilide Boceprevir Increased dofetilide exposure Details Dofetilide Brodalumab Increased dofetilide exposure Details Dofetilide Bumetanide Bumex An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Cannabis Increased dofetilide exposure Details Dofetilide Capivasertib Truqap Increased dofetilide exposure Details Dofetilide Chlorothiazide Diuril An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Chlorthalidone Hemiclor An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Chlorzoxazone Lorzone Increased dofetilide exposure Details Dofetilide Cilostazol Pletal® Increased dofetilide exposure Details Dofetilide Clopamide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Cobicistat Tybost Increased dofetilide exposure and an increased risk of dofetilide-related adverse effects Details Dofetilide Cyclopenthiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Cyclosporine Atopica Increased dofetilide exposure Details Dofetilide Cyclothiazide An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Daclatasvir Daklinza® Increased dofetilide exposure Details Dofetilide Darunavir Increased antiarrhythmic exposure and an increased risk of antiarrhythmic-related adverse effects Details Dofetilide Delavirdine Rescriptor® Increased dofetilide exposure Details Dofetilide Desogestrel Increased dofetilide exposure Details Dofetilide Diazoxide Proglycem An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Dofetilide Dienogest Increased dofetilide exposure Details Dofetilide Diltiazem Cardizem Increased dofetilide exposure Details Dofetilide Diosmin Increased dofetilide exposure Details

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