Dolasetron

332 interactions 1 explained in plain English 421 cited references

Also sold as: Anzemet Anzemet®

About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Phenelzine Saquinavir Pimozide Mesoridazine Sparfloxacin

16 Contraindicated 314 Major 1 Moderate 1 Minor

All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Major

Dolasetron Meperidine Demerol Increased risk of serotonin syndrome Details Dolasetron Metaxalone Skelaxin Increased risk of serotonin syndrome Details Dolasetron Methadone Diskets Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Methamphetamine Desoxyn An increased risk of serotonin syndrome Details Dolasetron Methylene Blue Provayblue Increased risk of serotonin syndrome Details Dolasetron Metronidazole Flagyl An increased risk of QT interval prolongation Details Dolasetron Mifepristone Korlym An increased risk of QT interval prolongation Details Dolasetron Milnacipran Savella Increased risk of serotonin syndrome Details Dolasetron Milsaperidone An increased risk of QT interval prolongation Details Dolasetron Mirtazapine Mirataz Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Dolasetron Mobocertinib Exkivity An increased risk of QT interval prolongation Details Dolasetron Moclobemide Increased risk of serotonin syndrome Details Dolasetron Morphine Increased risk of serotonin syndrome Details Dolasetron Morphine Sulfate Liposome Increased risk of serotonin syndrome Details Dolasetron Moxifloxacin Avelox Increased risk of QT interval prolongation Details Dolasetron Nalbuphine Increased risk of serotonin syndrome Details Dolasetron Naratriptan Increased risk of serotonin syndrome Details Dolasetron Nefazodone Increased risk of serotonin syndrome Details Dolasetron Nelfinavir Viracept Increased risk of QT interval prolongation Details Dolasetron Nilotinib An increased risk of QT interval prolongation Details Dolasetron Norfloxacin An increased risk of QT interval prolongation Details Dolasetron Nortriptyline Increased risk of serotonin syndrome Details Dolasetron Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Ofloxacin Floxin® An increased risk of QT interval prolongation Details Dolasetron Olanzapine An increased risk of QT interval prolongation Details Dolasetron Oliceridine Olinvyk Increased risk of serotonin syndrome Details Dolasetron Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Dolasetron Ondansetron An increased risk of serotonin syndrome and QT interval prolongation Details Dolasetron Opipramol Increased risk of serotonin syndrome Details Dolasetron Osilodrostat Isturisa Increased risk of QT interval prolongation Details Dolasetron Osimertinib Tagrisso Increased risk of QT interval prolongation Details Dolasetron Oxaliplatin Increased risk of QT-interval prolongation Details Dolasetron Oxycodone Oxaydo Increased risk of serotonin syndrome Details Dolasetron Oxymorphone Increased risk of serotonin syndrome Details Dolasetron Ozanimod Additive effects on heart rate Details Dolasetron Pacritinib Vonjo® An increased risk of QT interval prolongation Details Dolasetron Paliperidone Erzofri An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Palonosetron An increased risk of serotonin syndrome Details Dolasetron Panobinostat Farydak Increased risk of QT interval prolongation Details Dolasetron Paroxetine Paxil Increased risk of serotonin syndrome and QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.