Dolasetron

332 interactions 1 explained in plain English 421 cited references

Also sold as: Anzemet Anzemet®

About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Phenelzine Saquinavir Pimozide Mesoridazine Sparfloxacin

16 Contraindicated 314 Major 1 Moderate 1 Minor

All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Contraindicated

Dolasetron Apomorphine Apokyn Increased risk of profound hypotension and altered consciousness and an increased risk of QT interval prolongation, associated wit... Details Dolasetron Bepridil An increased risk of QT interval prolongation Details Dolasetron Cisapride Propulsid® Increased risk of QT interval prolongation Details Dolasetron Dronedarone Multaq Increased risk of QT interval prolongation Details Dolasetron Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Dolasetron Levomethadyl An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Mesoridazine An increased risk of QT interval prolongation Details Dolasetron Phenelzine Nardil An increased risk of serotonin syndrome Details Dolasetron Pimozide An increased risk of QT interval prolongation Details Dolasetron Piperaquine An increased risk of QT interval prolongation Details Dolasetron Saquinavir An increased risk of QT interval prolongation Details Dolasetron Sparfloxacin An increased risk of QT interval prolongation Details Dolasetron Terfenadine An increased risk of QT interval prolongation Details Dolasetron Thioridazine An increased risk of QT interval prolongation Details Dolasetron Tranylcypromine Parnate An increased risk of serotonin syndrome Details Dolasetron Ziprasidone Geodon Increased risk of QT interval prolongation and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, men... Details

Major

Dolasetron Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Dolasetron Amitriptyline Elavil Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Sertraline Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Dolasetron Buprenorphine Belbuca An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Dolasetron Relugolix Orgovyx Increased risk of QT interval prolongation Details Dolasetron Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Dolasetron Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Dolasetron Arsenic Trioxide Injection Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Dolasetron Azithromycin AzaSite An increased risk of QT interval prolongation Details Dolasetron Alfuzosin UroXatral An increased risk of QT interval prolongation Details Dolasetron Anagrelide Agrylin Increased risk of QT interval prolongation Details Dolasetron Bedaquiline Sirturo Increased risk of QT interval prolongation Details Dolasetron Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Dolasetron Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Dolasetron Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Dasatinib Phyrago An increased risk of QT interval prolongation Details Dolasetron Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Dolasetron Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Dolasetron Disopyramide Norpace Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Dofetilide Tikosyn Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Acecainide Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.