Lisdexamfetamine and Dolasetron: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dolasetron
Lisdexamfetamine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of serotonin syndrome
Interaction Deep Dive
Coadministration of an amphetamine and another serotonergic agent may result in serotonin syndrome, because both drugs affect the serotonergic neurotransmitter system12. Additionally there may be sustained increases in the concentration of d-amphetamine in the brain and cardiovascular effects can be potentiated 1. If concomitant use of an amphetamine and such an agent is clinically required, initiate with lower doses and monitor patients carefully, especially during treatment initiation and dosage adjustment. Discontinue both drugs if serotonin syndrome is suspected 32.
Why it happens (mechanism)
Additive serotonergic effects
Common questions
Can I take Lisdexamfetamine and Dolasetron together?
An increased risk of serotonin syndrome Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lisdexamfetamine and Dolasetron interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Lisdexamfetamine or Dolasetron need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: VYVANSE(R) oral capsules, oral chewable tablets, lisdexamfetamine dimesylate oral capsules, oral chewable tablets. Shire US Inc (per DailyMed), Lexington, MA, 2018. DailyMed
- Product Information: FETZIMA(R) oral extended-release capsules, levomilnacipran oral extended-release capsules. AbbVie Inc (per FDA), North Chicago, IL, 2023. DailyMed
- Product Information: ADDERALL(R) oral tablets, dextroamphetamine saccharate amphetamine aspartate dextroamphetamine sulfate amphetamine sulfate oral tablets. Teva Select Brands (per FDA), Horsham, PA, 2017. DailyMed
Keep reading about Dolasetron
Keep reading about Lisdexamfetamine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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