Lisdexamfetamine

55 interactions 7 explained in plain English
Also sold as: Arynta Vyvanse
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Lisdexamfetamine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Lisdexamfetamine Omeprazole Gastrobim Explained Increased exposure to amphetamine Details Lisdexamfetamine Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Lisdexamfetamine Sertraline Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Lisdexamfetamine Albuterol Oral Inhalation Accuneb® Explained Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Lisdexamfetamine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Lisdexamfetamine Dupilumab Injection Dupixent Explained Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Acetazolamide Diamox® Sequels® Increased exposure to amphetamine Details Lisdexamfetamine Asenapine Transdermal Patch Secuado Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Abiraterone Abirtega Increased amphetamine exposure and increased risk of serotonin syndrome Details Lisdexamfetamine Alogliptin Nesina Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Butorphanol Injection Butorphic An increased risk of serotonin syndrome Details Lisdexamfetamine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome Details Lisdexamfetamine Clonidine Transdermal Patch Catapres Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Lisdexamfetamine Dacomitinib Vizimpro Increased amphetamine exposure and increased risk of serotonin syndrome Details Lisdexamfetamine Dexlansoprazole Dexilant Increased exposure to amphetamine Details Lisdexamfetamine Diphenhydramine Injection Banophen Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Diphenhydramine Topical Afterbite with Antihistamine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Dolasetron Anzemet An increased risk of serotonin syndrome Details Lisdexamfetamine Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Lisdexamfetamine Dronabinol Marinol Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Droxidopa Northera Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Lisdexamfetamine Enasidenib Idhifa Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Esomeprazole Nexium Increased exposure to amphetamine Details Lisdexamfetamine Esomeprazole Injection Nexium Increased exposure to amphetamine Details Lisdexamfetamine Estradiol Delestrogen Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Estradiol Topical Divigel Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Estradiol Transdermal Patch Alora® Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Febuxostat Uloric Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Felodipine Plendil® Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Lisdexamfetamine Flecainide Tambocor® Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Gefitinib Iressa Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Lisdexamfetamine Granisetron Injection Granisol An increased risk of serotonin syndrome Details Lisdexamfetamine Hydralazine Apresoline® Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Lisdexamfetamine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Lisdexamfetamine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Lisdexamfetamine Hydroxychloroquine Plaquenil An increased risk of seizures, increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an incr... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.