Dolasetron

332 interactions 1 explained in plain English 421 cited references

Also sold as: Anzemet Anzemet®

About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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16 Contraindicated 314 Major 1 Moderate 1 Minor

All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Major

Dolasetron Ajmaline Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Alfentanil Increased risk of serotonin syndrome Details Dolasetron Almotriptan Increased risk of serotonin syndrome Details Dolasetron Amineptine Increased risk of serotonin syndrome Details Dolasetron Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Dolasetron Amitriptylinoxide Increased risk of serotonin syndrome Details Dolasetron Amoxapine Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Amphetamine Dexedrine An increased risk of serotonin syndrome Details Dolasetron Aprindine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Aripiprazole Abilify An increased risk of QT interval prolongation Details Dolasetron Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Dolasetron Artemether An increased risk of QT interval prolongation Details Dolasetron Asenapine Saphris Increased risk of QT interval prolongation Details Dolasetron Astemizole Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Atazanavir Reyataz An increased risk of QT interval prolongation Details Dolasetron Azimilide Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Benzhydrocodone An increased risk of serotonin syndrome Details Dolasetron Benzphetamine An increased risk of serotonin syndrome Details Dolasetron Bretylium Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Brompheniramine Respa-BR Increased risk of serotonin syndrome Details Dolasetron Buspirone Bucapsol Increased risk of serotonin syndrome Details Dolasetron Butorphanol Butorphic Increased risk of serotonin syndrome Details Dolasetron Carbamazepine Carbatrol Increased risk of serotonin syndrome Details Dolasetron Ceritinib Zykadia An increased risk of QT interval prolongation Details Dolasetron Chloral Hydrate An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Chlorpheniramine Increased risk of serotonin syndrome Details Dolasetron Chlorpromazine Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Ciprofloxacin An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Citalopram Celexa Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Clarithromycin Biaxin Increased risk of QT interval prolongation Details Dolasetron Clofazimine An increased risk of QT interval prolongation Details Dolasetron Clomipramine Anafranil Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Clothiapine Increased risk of cardiac arrhythmias Details Dolasetron Clozapine Clozaril Increased risk of QT interval prolongation Details Dolasetron Cocaine Goprelto Increased risk of serotonin syndrome Details Dolasetron Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of serotonin syndrome Details Dolasetron Crizotinib Xalkori An increased risk of QT interval prolongation Details Dolasetron Cyclobenzaprine Amrix Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Dabrafenib Tafinlar An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.