Dolasetron

332 interactions 1 explained in plain English 421 cited references

Also sold as: Anzemet Anzemet®

About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Phenelzine Saquinavir Pimozide Mesoridazine Sparfloxacin

16 Contraindicated 314 Major 1 Moderate 1 Minor

All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Major

Dolasetron Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details Dolasetron Solifenacin Vesicare An increased risk of QT interval prolongation Details Dolasetron Sorafenib Nexavar An increased risk of QT interval prolongation Details Dolasetron Sotalol Betapace An increased risk of QT interval prolongation Details Dolasetron Spiramycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron St John's Wort Increased risk of serotonin syndrome Details Dolasetron Sufentanil Dsuvia Increased risk of serotonin syndrome Details Dolasetron Sulfamethoxazole Sustain An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Sulpiride An increased risk of QT interval prolongation Details Dolasetron Sultopride An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Sumatriptan Imitrex Increased risk of serotonin syndrome Details Dolasetron Sunitinib Sutent An increased risk of QT interval prolongation Details Dolasetron Tacrolimus Astagraf An increased risk of QT interval prolongation Details Dolasetron Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Dolasetron Tapentadol Nucynta Increased risk of serotonin syndrome Details Dolasetron Tedisamil Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Tedizolid Phosphate Sivextro An increased risk of serotonin syndrome Details Dolasetron Telavancin Vibativ An increased risk of QT interval prolongation Details Dolasetron Telithromycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Tetrabenazine Xenazine An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Tianeptine Increased risk of serotonin syndrome Details Dolasetron Toremifene Fareston An increased risk of QT interval prolongation, ventricular tachycardia or an increased risk of torsade de pointes Details Dolasetron Tramadol ConZip Increased risk of serotonin syndrome Details Dolasetron Trazodone Raldesy Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Triclabendazole Egaten An increased risk of QT interval prolongation Details Dolasetron Trifluoperazine Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Trimethoprim Primsol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Trimipramine Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Triptorelin Increased risk of QT interval prolongation Details Dolasetron Tryptophan Increased risk of serotonin syndrome Details Dolasetron Vandetanib Caprelsa An increased risk of QT interval prolongation and Torsades de pointes Details Dolasetron Vardenafil Levitra An increased risk of QT interval prolongation Details Dolasetron Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Dolasetron Venlafaxine An increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Dolasetron Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Dolasetron Vilanterol An increased risk of QT interval prolongation Details Dolasetron Vilazodone Viibryd Increased risk of serotonin syndrome Details Dolasetron Vinflunine Increased risk of QT-interval prolongation Details Dolasetron Voclosporin Lupkynis An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.