Dolasetron

332 interactions 1 explained in plain English 421 cited references
Also sold as: Anzemet Anzemet®
About Dolasetron

Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Read the full Dolasetron drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Phenelzine Saquinavir Pimozide Mesoridazine Sparfloxacin
16 Contraindicated 314 Major 1 Moderate 1 Minor
All (332) Contraindicated (16) Major (314) Moderate (1) Minor (1)

Major

Dolasetron Voriconazole Vfend An increased risk of QT interval prolongation Details Dolasetron Vortioxetine Trintellix Increased risk of serotonin syndrome Details Dolasetron Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Dolasetron Zolmitriptan Zomig Increased risk of serotonin syndrome Details Dolasetron Zotepine An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Dolasetron Zuclopenthixol An increased risk of QT interval prolongation Details Dolasetron Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Dolasetron Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Dolasetron Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Dolasetron Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Dolasetron Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Dolasetron Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Dolasetron Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Dolasetron Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Dolasetron Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Dolasetron Lacosamide Injection Motpoly An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Dolasetron Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Dolasetron Linezolid Injection Zyvox Increased risk of serotonin syndrome Details Dolasetron Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Dolasetron Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Dolasetron Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Dolasetron Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Dolasetron Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Dolasetron Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Dolasetron Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Dolasetron Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Dolasetron Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dolasetron Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Dolasetron Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Dolasetron Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Dolasetron Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Dolasetron Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.