Doxazosin and Milsaperidone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Doxazosin
Milsaperidone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of symptomatic hypotension
Interaction Deep Dive
Avoid concomitant administration of milsaperidone with alpha-adrenergic blocking agents as it may cause symptomatic hypotension. Consider lowering the dosage of other drugs that lower blood pressure1.
Why it happens (mechanism)
Additive hypotensive effects
Common questions
Can I take Doxazosin and Milsaperidone together?
An increased risk of symptomatic hypotension Always confirm with your pharmacist or prescriber before making any change.
How serious is the Doxazosin and Milsaperidone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Doxazosin or Milsaperidone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: BYSANTI™ oral tablets, milsaperidone oral tablets. Vanda Pharmaceuticals Inc. (Per Manufacturer), Washington, D.C. 2026. DailyMed
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