Doxorubicin and Margetuximab: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Doxorubicin
Margetuximab
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of cardiac dysfunction
Interaction Deep Dive
Concurrent use of margetuximab-cmkb and anthracyclines may increase the incidence and severity of cardiac dysfunction, based on clinical data from other HER2-directed antibodies. Use of anthracyclines should be avoided during therapy and for 4 months following discontinuation of margetuximab-cmbk. If coadministration is unavoidable, monitor cardiac function carefully1.
Why it happens (mechanism)
Additive or synergistic myocardial damage
Common questions
Can I take Doxorubicin and Margetuximab together?
Increased risk of cardiac dysfunction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Doxorubicin and Margetuximab interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Doxorubicin or Margetuximab need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MARGENZA(TM) intravenous injection, margetuximab-cmkb intravenous injection. MacroGenics Inc (per manufacturer), Rockville, MD, 2020. DailyMed
Keep reading about Doxorubicin
Keep reading about Margetuximab
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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