Doxorubicin

237 interactions 822 cited references

Also sold as: Adriamycin Adriamycin® Caelyx Doxil Rubex®

About Doxorubicin

Doxorubicin is a chemotherapy drug used to treat various cancers including leukemia, lymphoma, and solid tumors. Read the full Doxorubicin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Varicella Virus Vaccine, Live Typhoid Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Tasonermin

12 Contraindicated 218 Major 5 Moderate 2 Minor

All (237) Contraindicated (12) Major (218) Moderate (5) Minor (2)

Contraindicated

Doxorubicin Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Cobicistat Tybost Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Mavorixafor Xolremdi Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Doxorubicin Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Doxorubicin Tasonermin Increased risk of cardiotoxicity Details Doxorubicin Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Doxorubicin Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Doxorubicin Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Doxorubicin Amitriptyline Elavil Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Sertraline Increased CYP2D6 substrate exposure Details Doxorubicin Abrocitinib Cibinqo Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Apixaban Eliquis Reduced apixaban exposure Details Doxorubicin Azathioprine Azasan An increased risk of hepatotoxicity Details Doxorubicin Azithromycin AzaSite Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Atorvastatin Atorvaliq Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Abiraterone Abirtega Increased DOXOrubicin exposure Details Doxorubicin Alogliptin Nesina Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Canagliflozin Invokana Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Doxorubicin Captopril Capoten® Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Cisplatin Injection Platinol-AQ® Leukemia Details Doxorubicin Clotrimazole Aardora Anti-Fungal Maximum Strength Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Doxorubicin Clotrimazole Lozenge Mycelex® Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Doxorubicin Clotrimazole Topical Cruex Antifungal Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Doxorubicin Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Doxorubicin Cyclophosphamide Cytoxan® Increased risk of cardiomyopathy Details Doxorubicin Cyclophosphamide Injection Cytoxan® Injection Increased risk of cardiomyopathy Details Doxorubicin Cyclosporine Injection Atopica Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Cyclosporine Ophthalmic Cequa Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Doxorubicin Dabigatran Pradaxa® Reduced dabigatran etexilate exposure Details Doxorubicin Dabigatran Etexilate Reduced dabigatran etexilate exposure Details Doxorubicin Dexamethasone Injection Decadron Reduced DOXOrubicin exposure Details Doxorubicin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced DOXOrubicin exposure Details Doxorubicin Abiraterone Acetate Abirtega Increased DOXOrubicin exposure Details Doxorubicin Abiraterone Acetate, Micronized Abirtega Increased DOXOrubicin exposure Details Doxorubicin Adagrasib Krazati Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.