Dronedarone

146 interactions 12 explained in plain English
Also sold as: Multaq
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Dronedarone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Dronedarone Ibrutinib Imbruvica Increased ibrutinib exposure Details Dronedarone Ifosfamide Injection Ifex Decreased ifosfamide effectiveness Details Dronedarone Infigratinib Truseltiq Increased infigratinib plasma concentrations Details Dronedarone Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Dronedarone Labetalol Normodyne® Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Dronedarone Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Dronedarone Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Dronedarone Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Dronedarone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Dronedarone Levobunolol Ophthalmic AKBeta® Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Lovastatin Altocor® Increased lovastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Dronedarone Lumateperone Caplyta Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Dronedarone Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Dronedarone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Dronedarone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dronedarone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dronedarone Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Dronedarone Midazolam Nasal Spray Nayzilam Increased midazolam exposure and increased risk for prolonged sedation Details Dronedarone Midazolam Injection Nayzilam Increased midazolam exposure and increased risk for prolonged sedation Details Dronedarone Mitapivat Aqvesme Increased mitapivat exposure and reduced CYP3A4 substrate exposure Details Dronedarone Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Dronedarone Nadolol Corgard Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Nafcillin Injection Unipen® Injection Reduced dronedarone exposure Details Dronedarone Naloxegol Movantik Increased naloxegol exposure Details Dronedarone Nebivolol Bystolic Increased exposure to some beta blockers and increased incidence of bradycardia Details Dronedarone Neratinib Nerlynx Increased neratinib exposure and risk of toxicity Details Dronedarone Nevirapine Viramune Reduced dronedarone exposure Details Dronedarone Nifedipine Adalat® Increased NIFEdipine exposure Details Dronedarone Olaparib Lynparza Increased olaparib exposure Details Dronedarone Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Dronedarone Penbutolol Levatol® Increased exposure to some beta blockers and increased incidence of bradycardia Details

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