Droxicam and Cholestyramine Resin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cholestyramine Resin
Droxicam
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased piroxicam effectiveness
Interaction Deep Dive
In eight healthy males the concurrent use of cholestyramine 4 g three times daily and piroxicam 20 mg orally resulted in an increased clearance, decreased half-life (28 hours vs 46 hours), and a decreased concentration of piroxicam1. Cholestyramine is an anion-exchange resin which binds acidic drugs in the gut.
Why it happens (mechanism)
Decreased piroxicam absorption
Common questions
Can I take Droxicam and Cholestyramine Resin together?
Decreased piroxicam effectiveness Always confirm with your pharmacist or prescriber before making any change.
How serious is the Droxicam and Cholestyramine Resin interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Droxicam or Cholestyramine Resin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Guentert TW, Defoin R, & Mosberg H: The influence of cholestyramine on the elimination of tenoxicam and piroxicam. Eur J Clin Pharmacol 1988; 34:283-289. PubMed
Keep reading about Cholestyramine Resin
Keep reading about Droxicam
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