Cholestyramine Resin

70 interactions 215 cited references

Also sold as: Locholest® Locholest® Light Prevalite Prevalite® Questran Questran® Questran® Light

About Cholestyramine Resin

Cholestyramine is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen… Read the full Cholestyramine Resin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bezafibrate Chenodiol Deferasirox Dexamethasone Digoxin Elafibranor

15 Major 41 Moderate 14 Minor

All (70) Major (15) Moderate (41) Minor (14)

Major

Cholestyramine Resin Bezafibrate Decreased bezafibrate efficacy Details Cholestyramine Resin Chenodiol Reduced chenodiol exposure and reduced efficacy of chenodiol Details Cholestyramine Resin Deferasirox Exjade Decreased deferasirox concentrations Details Cholestyramine Resin Dexamethasone Decreased dexamethasone concentration Details Cholestyramine Resin Digoxin Cardoxin® Reduced digoxin exposure Details Cholestyramine Resin Elafibranor Iqirvo Reduced elafibranor exposure and reduced efficacy of elafibranor Details Cholestyramine Resin Ezetimibe Zetia Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Cholestyramine Resin Fenofibrate Antara Reduced absorption of fenofibrate Details Cholestyramine Resin Fenofibric Acid Fibricor Reduced absorption of fenofibrate Details Cholestyramine Resin Linerixibat Reduced exposure of linerixibat and reduced efficacy of linerixibat Details Cholestyramine Resin Lomitapide Reduced lomitapide exposure Details Cholestyramine Resin Mycophenolate Mofetil Reduced exposure of mycophenolic acid (MPA) and reduced efficacy of mycophenolate mofetil Details Cholestyramine Resin Mycophenolic Acid Myfortic Reduced mycophenolic acid exposure Details Cholestyramine Resin Seladelpar Reduced seladelpar exposure and reduced efficacy of seladelpar Details Cholestyramine Resin Taurursodiol Reduced exposure of taurursodiol Details

Moderate

Cholestyramine Resin Aceclofenac Decreased diclofenac bioavailability Details Cholestyramine Resin Anisindione Decreased anticoagulant effectiveness Details Cholestyramine Resin Calcifediol Rayaldee Decreased absorption of calcifediol Details Cholestyramine Resin Cephalexin Keflet® Tablets Decreased cephalexin effectiveness Details Cholestyramine Resin Cerivastatin Reduced cerivastatin absorption and clinical efficacy Details Cholestyramine Resin Chlorothiazide Diuril Decreased chlorothiazide effectiveness Details Cholestyramine Resin Cholic Acid Decreased efficacy of cholic acid Details Cholestyramine Resin Diclofenac Aleve Arthritis Pain Decreased diclofenac bioavailability Details Cholestyramine Resin Dicumarol Decreased effects of dicumarol Details Cholestyramine Resin Digitoxin Decreased digitoxin effectiveness Details Cholestyramine Resin Diltiazem Cardizem Decreased diltiazem bioavailability Details Cholestyramine Resin Entacapone Comtan Enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Cholestyramine Resin Estetrol Decreased estetrol and drospirenone exposure Details Cholestyramine Resin Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Cholestyramine Resin Furosemide Disal Decreased furosemide effectiveness Details Cholestyramine Resin Hydrochlorothiazide Inzirqo Decreased hydrochlorothiazide concentration Details Cholestyramine Resin Iopanoic Acid Abnormal cholecystography results Details Cholestyramine Resin Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Cholestyramine Resin Liothyronine Cytomel Decreased effectiveness of liothyronine Details Cholestyramine Resin Maralixibat Livmarli Reduced exposure and efficacy of maralixibat Details Cholestyramine Resin Meloxicam Alloxate An increased clearance of meloxicam Details Cholestyramine Resin Methacycline Decreased methacycline concentrations Details Cholestyramine Resin Methotrexate Jylamvo Decreased methotrexate effectiveness Details Cholestyramine Resin Metronidazole Flagyl Decreased metronidazole effectiveness Details Cholestyramine Resin Obeticholic Acid Ocaliva Reduced exposure and efficacy of obeticholic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.