Cholestyramine Resin

70 interactions 215 cited references

Also sold as: Locholest® Locholest® Light Prevalite Prevalite® Questran Questran® Questran® Light

About Cholestyramine Resin

Cholestyramine is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen… Read the full Cholestyramine Resin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bezafibrate Chenodiol Deferasirox Dexamethasone Digoxin Elafibranor

15 Major 41 Moderate 14 Minor

All (70) Major (15) Moderate (41) Minor (14)

Moderate

Cholestyramine Resin Aceclofenac Decreased diclofenac bioavailability Details Cholestyramine Resin Anisindione Decreased anticoagulant effectiveness Details Cholestyramine Resin Calcifediol Rayaldee Decreased absorption of calcifediol Details Cholestyramine Resin Cephalexin Keflet® Tablets Decreased cephalexin effectiveness Details Cholestyramine Resin Cerivastatin Reduced cerivastatin absorption and clinical efficacy Details Cholestyramine Resin Chlorothiazide Diuril Decreased chlorothiazide effectiveness Details Cholestyramine Resin Cholic Acid Decreased efficacy of cholic acid Details Cholestyramine Resin Diclofenac Aleve Arthritis Pain Decreased diclofenac bioavailability Details Cholestyramine Resin Dicumarol Decreased effects of dicumarol Details Cholestyramine Resin Digitoxin Decreased digitoxin effectiveness Details Cholestyramine Resin Diltiazem Cardizem Decreased diltiazem bioavailability Details Cholestyramine Resin Entacapone Comtan Enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Cholestyramine Resin Estetrol Decreased estetrol and drospirenone exposure Details Cholestyramine Resin Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Cholestyramine Resin Furosemide Disal Decreased furosemide effectiveness Details Cholestyramine Resin Hydrochlorothiazide Inzirqo Decreased hydrochlorothiazide concentration Details Cholestyramine Resin Iopanoic Acid Abnormal cholecystography results Details Cholestyramine Resin Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Cholestyramine Resin Liothyronine Cytomel Decreased effectiveness of liothyronine Details Cholestyramine Resin Maralixibat Livmarli Reduced exposure and efficacy of maralixibat Details Cholestyramine Resin Meloxicam Alloxate An increased clearance of meloxicam Details Cholestyramine Resin Methacycline Decreased methacycline concentrations Details Cholestyramine Resin Methotrexate Jylamvo Decreased methotrexate effectiveness Details Cholestyramine Resin Metronidazole Flagyl Decreased metronidazole effectiveness Details Cholestyramine Resin Obeticholic Acid Ocaliva Reduced exposure and efficacy of obeticholic acid Details Cholestyramine Resin Odevixibat Bylvay Reduced exposure and efficacy of odevixibat Details Cholestyramine Resin Paricalcitol Zemplar Decreased systemic paricalcitol concentrations Details Cholestyramine Resin Penicillin G Decreased penicillin G absorption Details Cholestyramine Resin Phenobarbital Fidoquel Decreased phenobarbital absorption Details Cholestyramine Resin Phenprocoumon Decreased effects of phenprocoumon Details Cholestyramine Resin Phenylbutazone Equi-Phar Decreased phenylbutazone absorption Details Cholestyramine Resin Pravastatin Pravachol Reduced effectiveness of pravastatin Details Cholestyramine Resin Propranolol Hemangeol Decreased propranolol exposure Details Cholestyramine Resin Raloxifene Evista Reduced raloxifene absorption and clinical efficacy Details Cholestyramine Resin Tetracycline Achromycin V® Decreased tetracycline absorption Details Cholestyramine Resin Thyroglobulin Decreased thyroid effectiveness Details Cholestyramine Resin Tinidazole Tindamax Decreased tinidazole effectiveness Details Cholestyramine Resin Torsemide Soaanz Decreased levels of torsemide Details Cholestyramine Resin Troglitazone Reduced absorption of troglitazone Details Cholestyramine Resin Valproic Acid Depakene® Decreased serum valproic acid concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.