Duloxetine

77 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Metoclopramide Injection Metoclopramide Nasal Spray Ketorolac Injection Palonosetron Injection Dacomitinib
3 Contraindicated 64 Major 10 Moderate
All (77) Contraindicated (3) Major (64) Moderate (10)

Major

Duloxetine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Duloxetine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Duloxetine Ibuprofen Addaprin An increased risk of bleeding Details Duloxetine Iloprost Aurlumyn An increased risk of bleeding Details Duloxetine Ketoprofen Actron® An increased risk of bleeding Details Duloxetine Ketorolac Acular An increased risk of bleeding Details Duloxetine Ketorolac Injection Acular An increased risk of bleeding Details Duloxetine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Duloxetine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Duloxetine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Duloxetine Meclofenamate Meclodium® An increased risk of bleeding Details Duloxetine Mefenamic Acid Ponstel® An increased risk of bleeding Details Duloxetine Meloxicam Alloxate An increased risk of bleeding Details Duloxetine Meloxicam Injection Alloxate An increased risk of bleeding Details Duloxetine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Duloxetine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Duloxetine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Duloxetine Mexiletine Mexitil® Increased CYP2D6 substrate exposure Details Duloxetine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Duloxetine Nabumetone Relafen An increased risk of bleeding Details Duloxetine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Duloxetine Naproxen Aleve An increased risk of bleeding Details Duloxetine Nebivolol Bystolic Increased exposure to nebivolol Details Duloxetine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.