Duloxetine
77 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Linezolid Injection
Metoclopramide Injection
Metoclopramide Nasal Spray
Ketorolac Injection
Palonosetron Injection
Dacomitinib
Major
Duloxetine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Duloxetine Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased CYP2D6 substrate exposure Details Duloxetine Sertraline Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Duloxetine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Duloxetine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Duloxetine Aripiprazole Injection Abilify Increased CYP2D6 substrate exposure Details Duloxetine Asenapine Transdermal Patch Secuado Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Duloxetine Aspirin Acuprin® An increased risk of bleeding Details Duloxetine Aspirin Rectal Aspirin An increased risk of bleeding Details Duloxetine Azathioprine Azasan An increased risk of hepatotoxicity Details Duloxetine Betrixaban Bevyxxa® An increased risk of bleeding Details Duloxetine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Duloxetine Anagrelide Agrylin An increased risk of bleeding Details Duloxetine Brexpiprazole Rexulti Increased brexpiprazole exposure Details Duloxetine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Duloxetine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Duloxetine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Duloxetine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Duloxetine Clopidogrel Plavix An increased risk of bleeding Details Duloxetine Dacomitinib Vizimpro Increased DULoxetine exposure and an increased risk of DULoxetine-related adverse effects Details Duloxetine Deferasirox Exjade Increased duloxetine exposure Details Duloxetine Deutetrabenazine Austedo Increased CYP2D6 substrate exposure Details Duloxetine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Duloxetine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Duloxetine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Duloxetine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Duloxetine Dipyridamole Permole® An increased risk of bleeding Details Duloxetine Dolasetron Anzemet Increased risk of serotonin syndrome Details Duloxetine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Duloxetine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Duloxetine Edoxaban Savaysa Increased risk of bleeding Details Duloxetine Epoprostenol Flolan An increased risk of bleeding Details Duloxetine Etodolac Lodine An increased risk of bleeding Details Duloxetine Fenoprofen Fenopron An increased risk of bleeding Details Duloxetine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Duloxetine Flecainide Tambocor® Increased class IC antiarrhythmic serum concentrations and an increased risk of cardiotoxicity (QT prolongation, torsades de point... Details Duloxetine Flurbiprofen Ansaid An increased risk of bleeding Details Duloxetine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Duloxetine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Duloxetine Granisetron Injection Granisol Increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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