Eliglustat

Name: Eliglustat Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

17 interactions 3 explained in plain English

Also sold as: Cerdelga

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Letermovir Injection Dofetilide Doxorubicin Ketoconazole Topical Loperamide

1 Contraindicated 16 Major

All (17) Contraindicated (1) Major (16)

Contraindicated

Eliglustat Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details

Major

Eliglustat Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Eliglustat Relugolix Orgovyx Explained Increased relugolix exposure Details Eliglustat Asenapine Transdermal Patch Secuado Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Eliglustat Abiraterone Abirtega Increased eliglustat exposure and an increased risk of cardiac arrhythmias from prolongation of the PR, QTc and/or QRS cardiac int... Details Eliglustat Brexpiprazole Rexulti Increased brexpiprazole exposure Details Eliglustat Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Eliglustat Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Eliglustat Digoxin Cardoxin® Increased digoxin exposure Details Eliglustat Disopyramide Norpace Increased risk of cardiac arrhythmias Details Eliglustat Dofetilide Tikosyn Increased risk of cardiac arrhythmias Details Eliglustat Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Eliglustat Ketoconazole Topical Extina® Foam Increased eliglustat exposure and an increased risk of cardiac arrhythmias from prolongation of the PR, QTc and/or QRS cardiac int... Details Eliglustat Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Eliglustat Letermovir Injection Prevymis Increased eliglustat exposure and an increased risk of cardiac arrhythmias from prolongation of the PR, QTc and/or QRS cardiac int... Details Eliglustat Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Eliglustat Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.