Entecavir

Name: Entecavir Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions 44 cited references

Also sold as: Baraclude Baraclude®

About Entecavir

Entecavir is used to treat chronic (long-term) hepatitis B infection (swelling of the liver caused by a virus) in adults and children 2 years of age and older who have liver damage. Entecavir is in a class of medications called nucleoside analogs. It works by decreasing the amount of hepatitis B virus (HBV) in the body… Read the full Entecavir drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Levoketoconazole Mercaptopurine Methotrexate Methotrexate Injection

5 Major

All (5) Major (5)

Major

Entecavir Azathioprine Azasan An increased risk of hepatotoxicity Details Entecavir Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Entecavir Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Entecavir Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Entecavir Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.