Esmolol

191 interactions 1 explained in plain English 406 cited references

Also sold as: Brevibloc

Read the full Esmolol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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36 Major 155 Moderate

All (191) Major (36) Moderate (155)

Moderate

Esmolol Acarbose Prandase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Esmolol Aspirin Acuprin® Reduced antihypertensive effect Details Esmolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Esmolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Esmolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Esmolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Esmolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Esmolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Esmolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Esmolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Aceclofenac Reduced antihypertensive effect Details Esmolol Acemetacin Reduced antihypertensive effect Details Esmolol Acetyldigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Esmolol Albiglutide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Amtolmetin Guacil Reduced antihypertensive effect Details Esmolol Asenapine Saphris An increased risk of hypotension Details Esmolol Atazanavir Reyataz An increased risk of PR interval prolongation Details Esmolol Bromfenac Bromsite Reduced antihypertensive effect Details Esmolol Bufexamac Reduced antihypertensive effect Details Esmolol Bunazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Carbimazole Altered metabolism of the beta-adrenergic blocker Details Esmolol Celecoxib Celebrex Reduced antihypertensive effect Details Esmolol Chlorpropamide Diabinese® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Choline Salicylate Reduced antihypertensive effect Details Esmolol Clonixin Reduced antihypertensive effect Details Esmolol Cobicistat Tybost Increased antiarrhythmic exposure Details Esmolol Deslanoside Increased risk of bradycardia and possible digitalis glycoside toxicity Details Esmolol Dexibuprofen Reduced antihypertensive effect Details Esmolol Dexketoprofen Reduced antihypertensive effect Details Esmolol Diclofenac Aleve Arthritis Pain Reduced antihypertensive effect Details Esmolol Diflunisal Dolobid Reduced antihypertensive effect Details Esmolol Digitoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details

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