Esmolol
191 interactions 1 explained in plain English 406 cited references
Also sold as:
Brevibloc
Read the full Esmolol drug information page
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Aug 10, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Olodaterol Oral Inhalation
Clonidine Transdermal Patch
Verapamil
Terbutaline
Taletrectinib
Siponimod
Major
Esmolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Esmolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Esmolol Albuterol ProAir Reduced efficacy of albuterol Details Esmolol Ceritinib Zykadia Increased risk of bradycardia Details Esmolol Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Esmolol Crizotinib Xalkori An increased risk of bradycardia Details Esmolol Darunavir Increased beta blocker/antiarrhythmic exposure, increased risk of beta blocker/antiarrhythmic-related adverse effects Details Esmolol Diltiazem Cardizem An increased risk of hypotension, bradycardia and slow AV conduction Details Esmolol Dronedarone Multaq Increased exposure to some beta blockers and increased incidence of bradycardia Details Esmolol Epinephrine An increased risk of cardiac arrhythmias, an antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increas... Details Esmolol Fenoldopam Exaggeration of hypotensive response Details Esmolol Fexinidazole Increased risk of bradycardia Details Esmolol Fingolimod Gilenya Slowing of the heart rate or atrioventricular conduction, which may result in severe bradycardia or heart block Details Esmolol Formoterol Perforomist Reduced efficacy of formoterol or reduced efficacy of beta-adrenergic blocker Details Esmolol Indacaterol Decreased efficacy of indacaterol Details Esmolol Insulin Afrezza Increased or reduced blood glucose lowering effect of insulin and reduced symptoms of hypoglycemia Details Esmolol Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia, which may sometimes be followed by hyperglycemia and an increased risk of blunted recognition o... Details Esmolol Iohexol Lower threshold for contrast reactions, increased risk of more severe contrast reaction, reduced efficacy when treating hypersensi... Details Esmolol Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Esmolol Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Esmolol Levalbuterol Xopenex Reduced efficacy of levalbuterol Details Esmolol Melatonin An increased risk of suppression of endogenous melatonin levels Details Esmolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Esmolol Olodaterol Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details Esmolol Phenelzine Nardil An increased risk of exaggerated hypotensive effect and an increased risk of bradycardia Details Esmolol Ponesimod Ponvory An increased risk of severe bradycardia and heart block Details Esmolol Rivastigmine Exelon Additive bradycardic effects Details Esmolol Salmeterol Serevent Reduced efficacy of salmeterol Details Esmolol Siponimod Mayzent An increased risk of severe bradycardia and heart block Details Esmolol Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Esmolol Terbutaline Brethine® Reduced efficacy of terbutaline Details Esmolol Verapamil Calan An increased risk of hypotension, bradycardia and slow AV conduction Details Esmolol Vilanterol Decreased efficacy of vilanterol Details Esmolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Esmolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Esmolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure DetailsModerate
Esmolol Acarbose Prandase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Esmolol Aspirin Acuprin® Reduced antihypertensive effect Details Esmolol Aspirin Rectal Aspirin Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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