Esmolol and Etrasimod: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Esmolol
Etrasimod
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
May increase the risk of transient decrease in heart rate
Interaction Deep Dive
A transient decrease in heart rate and AV conduction delays may occur when initiating etrasimod. Concomitant use of etrasimod in patients receiving stable beta blocker treatment did not result in additive effects on heart rate reduction, hence can be initiated in patients receiving stable doses of beta blocker treatment. However, the risk of additive heart rate reduction following initiation of beta blocker therapy with stable etrasimod treatment or concomitant use with other drugs that may decrease heart rate is unknown, hence seek the advice of a cardiologist before initiating a beta blocker in a patient receiving stable etrasimod treatment or concomitant use with other drugs that may decrease heart rate1.
Why it happens (mechanism)
Additive heart rate reduction
Common questions
Can I take Esmolol and Etrasimod together?
May increase the risk of transient decrease in heart rate Always confirm with your pharmacist or prescriber before making any change.
How serious is the Esmolol and Etrasimod interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Esmolol or Etrasimod need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: VELSIPITY(TM) oral tablets, etrasimod oral tablets. Pfizer Labs (per FDA), New York, NY, 2023. DailyMed
Keep reading about Esmolol
Keep reading about Etrasimod
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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