Esmolol

191 interactions 1 explained in plain English 406 cited references

Also sold as: Brevibloc

Read the full Esmolol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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36 Major 155 Moderate

All (191) Major (36) Moderate (155)

Moderate

Esmolol Meclofenamate Meclodium® Reduced antihypertensive effect Details Esmolol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Esmolol Meloxicam Alloxate Reduced antihypertensive effect Details Esmolol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Methacholine Impaired reversal of methacholine-caused bronchoconstriction Details Esmolol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Esmolol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Esmolol Metildigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Esmolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Morniflumate Reduced antihypertensive effect Details Esmolol Morphine Esmolol toxicity (bradycardia, hypotension) Details Esmolol Morphine Sulfate Liposome Esmolol toxicity (bradycardia, hypotension) Details Esmolol Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Nabumetone Relafen Reduced antihypertensive effect Details Esmolol Naproxen Aleve Reduced antihypertensive effect Details Esmolol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Nepafenac Ilevro Reduced antihypertensive effect Details Esmolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Esmolol Niflumic Acid Reduced antihypertensive effect Details Esmolol Nimesulide Reduced antihypertensive effect Details Esmolol Nimesulide Beta Cyclodextrin Reduced antihypertensive effect Details Esmolol Oxaprozin Coxanto Reduced antihypertensive effect Details Esmolol Oxyphenbutazone Reduced antihypertensive effect Details Esmolol Paltusotine Palsonify An increased risk of PR interval prolongation Details Esmolol Parecoxib Reduced antihypertensive effect Details Esmolol Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Phenylbutazone Equi-Phar Reduced antihypertensive effect Details Esmolol Piketoprofen Reduced antihypertensive effect Details Esmolol Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Piroxicam Feldene Reduced antihypertensive effect Details Esmolol Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Pranoprofen Reduced antihypertensive effect Details Esmolol Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Proglumetacin Reduced antihypertensive effect Details Esmolol Propyphenazone Reduced antihypertensive effect Details Esmolol Proquazone Reduced antihypertensive effect Details Esmolol Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Rofecoxib Reduced antihypertensive effect Details Esmolol Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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