Esmolol

191 interactions 1 explained in plain English 406 cited references

Also sold as: Brevibloc

Read the full Esmolol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Olodaterol Oral Inhalation Clonidine Transdermal Patch Verapamil Terbutaline Taletrectinib Siponimod

36 Major 155 Moderate

All (191) Major (36) Moderate (155)

Moderate

Esmolol Salicylic Acid Reduced antihypertensive effect Details Esmolol Salsalate Disalcid Reduced antihypertensive effect Details Esmolol Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Sodium Salicylate Reduced antihypertensive effect Details Esmolol Sulindac Clinoril® Reduced antihypertensive effect Details Esmolol Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Tenoxicam Reduced antihypertensive effect Details Esmolol Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Tiaprofenic Acid Reduced antihypertensive effect Details Esmolol Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Tolbutamide Orinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Tolfenamic Acid Reduced antihypertensive effect Details Esmolol Tolmetin Tolectin 600 Reduced antihypertensive effect Details Esmolol Tranylcypromine Parnate An increased risk of more pronounced bradycardia and postural hypotension Details Esmolol Trimazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Urapidil An exaggerated hypotensive response to the first dose of the alpha blocker Details Esmolol Valdecoxib Reduced antihypertensive effect Details Esmolol Vildagliptin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Yohimbine Reduced beta-adrenergic blocker effectiveness Details Esmolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Esmolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Esmolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Esmolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Esmolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Ketorolac Injection Acular Reduced antihypertensive effect Details Esmolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Esmolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Esmolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Esmolol Meloxicam Injection Alloxate Reduced antihypertensive effect Details Esmolol Morphine Injection Astramorph® PF Esmolol toxicity (bradycardia, hypotension) Details

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