Esomeprazole

Name: Esomeprazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

106 interactions 452 cited references

Also sold as: Nexium Nexium® Nexium® 24HR

About Esomeprazole

Esomeprazole is a proton pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Esomeprazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rilpivirine Dacomitinib Belumosudil Alfentanil Amphetamine Octreotide Injection

1 Contraindicated 83 Major 21 Moderate 1 Minor

All (106) Contraindicated (1) Major (83) Moderate (21) Minor (1)

Major

Esomeprazole Methylphenidate Transdermal Patch Daytrana Altered pharmacodynamic and changes in release profile of methylphenidate Details Esomeprazole Nivolumab Injection Opdivo Reduced efficacy of nivolumab Details Esomeprazole Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.