Estazolam

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Rectal Buprenorphine Fentanyl Transdermal Patch Butorphanol Injection Butorphanol Nasal Spray Nalbuphine Injection
21 Major 1 Moderate
All (22) Major (21) Moderate (1)

Major

Estazolam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Estazolam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Estazolam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Estazolam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Estazolam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Estazolam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Estazolam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Estazolam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Estazolam Diazepam Rectal Diastat Increased risk of CNS depression Details Estazolam Esketamine Nasal Spray Spravato Increased risk of sedation Details Estazolam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Estazolam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Estazolam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Estazolam Lacosamide Injection Motpoly An increased risk of CNS depression Details Estazolam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Estazolam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Estazolam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Estazolam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Estazolam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Estazolam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Estazolam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Estazolam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.