Estradiol

Major

Estradiol Cefuroxime Ceftin® Decreased contraceptive effectiveness Details Estradiol Cenobamate Xcopri Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Ceritinib Zykadia Increased CYP3A substrate exposure Details Estradiol Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details Estradiol Clobazam Onfi Decreased contraceptive effectiveness Details Estradiol Cloxacillin Decreased contraceptive effectiveness Details Estradiol Clozapine Clozaril Increased clozapine exposure and increased risk of adverse effects Details Estradiol Conivaptan Vaprisol Increased CYP3A substrate exposure Details Estradiol Cosyntropin Increased cortisol exposure Details Estradiol Cyclacillin Decreased contraceptive effectiveness Details Estradiol Cyclosporine Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Estradiol Dabrafenib Tafinlar Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Darunavir Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and an increased darunavir exposure Details Estradiol Dexamethasone Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Estradiol Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Estradiol Dicloxacillin Reduced hormonal contraceptive exposure, reduced hormonal contraceptive effectiveness and an increased risk of breakthrough bleedi... Details Estradiol Donepezil Adlarity Reduced seizure threshold Details Estradiol Doxycycline Acticlate Reduced efficacy of oral contraceptive Details Estradiol Efavirenz Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Estradiol Elafibranor Iqirvo Reduced hormonal contraceptives exposure, reduced efficacy of hormonal contraceptives and/or an increased risk of breakthrough ble... Details Estradiol Elagolix Orilissa Increased estrogen exposure, reduced progestin efficacy, and reduced elagolix efficacy Details Estradiol Elvitegravir Altered contraceptive effectiveness and risk of side effects Details Estradiol Enzalutamide Xtandi Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Estradiol Eslicarbazepine Acetate Aptiom Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Etravirine Intelence Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Estradiol Exenatide Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Estradiol Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Estradiol Fexinidazole An increased CYP3A4 substrate exposure Details Estradiol Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Estradiol Fosamprenavir Lexiva Reduced amprenavir exposure, altered hormonal levels, loss of contraceptive efficacy, and an increased risk of liver enzyme elevat... Details Estradiol Fosaprepitant Emend Injection Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Estradiol Fosnetupitant Increased exposure of CYP3A4 substrate Details Estradiol Fosphenytoin Cerebyx An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Estradiol Griseofulvin Fulvicin P/G Decreased contraceptive effectiveness Details Estradiol Guar Gum Reduced contraceptive effectiveness Details Estradiol Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Estradiol Hydroxychloroquine Plaquenil An increased risk of seizures Details Estradiol Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Estradiol Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details