Estradiol Interactions
Estrogen is used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause ('change of life', the end of monthly menstrual periods). Some brands of estrogen are also used to treat vaginal dryness, itching, or burning, or to prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who are experiencing or have experienced menopause. However, women who need a medication only to treat vaginal dryness or only to prevent osteoporosis should consider a different treatment. Some brands of estrogen are also to relieve symptoms of low estrogen in young women who do not produce enough estrogen naturally. Some brands of estrogen are also used to relieve the symptoms of certain types of breast and prostate (a male reproductive gland) cancer. Estrogen is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.
Brand Names Associated with Estradiol
- Amnestrogen® (esterified estrogens)
- Cenestin® (conjugated synthetic A estrogens)
- conjugated estrogens
- Covaryx® (as a combination product containing Esterified Estrogens, Methyltestosterone)
- Enjuvia® (conjugated synthetic B estrogens)
- Essian® (as a combination product containing Esterified Estrogens, Methyltestosterone)
- esterified estrogens
- Estrace® Tablets (estradiol)
- estradiol
- Estratab® (esterified estrogens)
- Estratest® (as a combination product containing Esterified Estrogens, Methyltestosterone)
- Estrogen
- estropipate
- Evex® (esterified estrogens)
- Femogen® (esterified estrogens)
- Femtest® (as a combination product containing Esterified Estrogens, Methyltestosterone)
- Menest® (esterified estrogens)
- Menogen® (as a combination product containing Esterified Estrogens, Methyltestosterone)
- Menrium® (as a combination product containing Chlordiazepoxide, Esterified Estrogens)
- Milprem® (as a combination product containing Conjugated Estrogens, Meprobamate)
- Ogen® Tablets (estropipate)
- Ortho-est® (estropipate)
- PMB® (as a combination product containing Conjugated Estrogens, Meprobamate)
- Premarin® Tablets (conjugated estrogens)
- Premarin® with Methyltestosterone (as a combination product containing Conjugated Estrogens, Methyltestosterone)
- Syntest® (as a combination product containing Esterified Estrogens, Methyltestosterone)
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- Contraindicated
- Major
- Amoxicillin
- Prednisone
- Valproic Acid
- Tirzepatide
- Bupropion
- Topiramate
- Abametapir
- Amifampridine
- Ampicillin
- Amprenavir
- Apalutamide
- Aprepitant
- Armodafinil
- Artemether
- Bacampicillin
- Belzutifan
- Betamethasone
- Bexarotene
- Bosentan
- Carbamazepine
- Carbenicillin
- Cefaclor
- Cefadroxil
- Cefdinir
- Cefditoren
- Cefixime
- Cefpodoxime
- Cefprozil
- Ceftazidime
- Ceftibuten
- Cefuroxime
- Cenobamate
- Ceritinib
- Clobazam
- Cloxacillin
- Colesevelam
- Conivaptan
- Cyclacillin
- Cyclosporine
- Dabrafenib
- Darunavir
- Dexamethasone
- Dicloxacillin
- Donepezil
- Doxycycline
- Efavirenz
- Elagolix
- Elvitegravir
- Encorafenib
- Enzalutamide
- Eslicarbazepine Acetate
- Etravirine
- Fedratinib
- Fexinidazole
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Fosphenytoin
- Griseofulvin
- Guar Gum
- Isotretinoin
- Itraconazole
- Ivosidenib
- Lesinurad
- Lixisenatide
- Lorlatinib
- Lumacaftor
- Mavacamten
- Meropenem
- Minocycline
- Mitapivat
- Mitotane
- Mobocertinib
- Modafinil
- Mycophenolate Mofetil
- Mycophenolic Acid
- Nafcillin
- Nelfinavir
- Netupitant
- Nevirapine
- Octreotide
- Oxacillin
- Oxcarbazepine
- Oxytetracycline
- Penicillin G
- Penicillin G Procaine
- Penicillin V
- Phenobarbital
- Phenylbutazone
- Phenytoin
- Pitolisant
- Pixantrone
- Prednisolone
- Primidone
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rufinamide
- Secobarbital
- Somatrogon-ghla
- St John's Wort
- Sugammadex
- Sultamicillin
- Tazemetostat
- Telaprevir
- Tetracycline
- Theophylline
- Ticarcillin
- Tigecycline
- Tizanidine
- Ulipristal
- Amoxicillin; Clavulanate
- Moderate
- Levothyroxine
- Metformin
- Warfarin
- Lamotrigine
- Amiodarone
- Atazanavir
- Diazepam
- Dicumarol
- Ginseng
- Hydrocortisone
- Minor
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.