Estradiol

216 interactions 765 cited references

Also sold as: Delestrogen

Read the full Estradiol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Tranexamic Acid Ensitrelvir Cloxacillin Isotretinoin Clozapine

3 Contraindicated 170 Major 31 Moderate 12 Minor

All (216) Contraindicated (3) Major (170) Moderate (31) Minor (12)

Contraindicated

Estradiol Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Estradiol Fezolinetant Increased fezolinetant exposure Details Estradiol Tranexamic Acid Cyklokapron An increased risk of thrombotic events Details

Major

Estradiol Abametapir Increased exposure of CYP3A4 substrate Details Estradiol Isotretinoin Absorica Decreased effectiveness of hormonal contraceptives Details Estradiol Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Estradiol Ampicillin Amcill® Decreased contraceptive effectiveness Details Estradiol Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Estradiol Bexarotene Targretin Decreased contraceptive effectiveness Details Estradiol Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Estradiol Cefaclor Ceclor® Decreased contraceptive effectiveness Details Estradiol Cefadroxil Duricef® Decreased contraceptive effectiveness Details Estradiol Cefdinir Omnicef® Decreased contraceptive effectiveness Details Estradiol Cefixime Suprax Decreased contraceptive effectiveness Details Estradiol Cefprozil Cefzil® Decreased contraceptive effectiveness Details Estradiol Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Estradiol Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Estradiol Colesevelam Welchol Decreased contraceptive effectiveness Details Estradiol Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Estradiol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Estradiol Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Estradiol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Estradiol Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Estradiol Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Estradiol Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Estradiol Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Estradiol Amifampridine Increased risk of seizures Details Estradiol Amprenavir Reduced amprenavir exposure, altered hormonal levels, loss of contraceptive efficacy, and an increased risk of liver enzyme elevat... Details Estradiol Apalutamide Erleada Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Estradiol Armodafinil Nuvigil Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Avacopan Tavneos Increased CYP3A4 substrate exposure Details Estradiol Bacampicillin Decreased contraceptive effectiveness Details Estradiol Belzutifan Welireg An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Estradiol Betamethasone Betavet Increased corticosteroid effects Details Estradiol Bosentan Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Estradiol Bupropion Aplenzin Increased risk of seizures Details Estradiol Carbamazepine Carbatrol Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Estradiol Carbenicillin Decreased contraceptive effectiveness Details Estradiol Cefditoren Spectracef® Decreased contraceptive effectiveness Details

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