Estradiol

Major

Estradiol Phenylbutazone Equi-Phar Reduced contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleeding and/or... Details Estradiol Phenytoin Dilantin An increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure, an increased risk of phenytoin or fosphenytoin toxicity (a... Details Estradiol Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Estradiol Pitolisant Wakix Reduced efficacy of hormonal contraceptives Details Estradiol Pixantrone Increased CYP1A2 substrate exposure Details Estradiol Prednisolone Flo-Pred® Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Estradiol Prednisone Deltasone Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased predniSONE exposure and an incre... Details Estradiol Primidone Mysoline Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Estradiol Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Estradiol Repotrectinib Augtyro Reduced hormonal contraceptive exposure, reduced effectiveness of hormonal contraceptive and an increased risk of breakthrough ble... Details Estradiol Rifabutin Mycobutin Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Rifampin Rifadin Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Estradiol Rifapentine Priftin Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Ritonavir Norvir Reduced estrogen/progestin exposure and reduced efficacy of contraceptive Details Estradiol Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Estradiol Rufinamide Banzel Reduced contraceptive exposure, reduced efficacy of combination contraceptives and an increased risk of breakthrough bleeding/cont... Details Estradiol Secobarbital Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Estradiol Somatrogon-Ghla Reduced somatrogon-ghla efficacy Details Estradiol St John's Wort Reduced hormonal contraceptive exposure and increased risk of contraceptive failure Details Estradiol Sugammadex Decreased contraceptive serum concentration and efficacy Details Estradiol Sultamicillin Decreased contraceptive effectiveness Details Estradiol Sunvozertinib Zegfrovy Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Estradiol Tazemetostat Tazverik Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Estradiol Telaprevir Decreased contraceptive effectiveness Details Estradiol Tetracycline Achromycin V® Decreased contraceptive effectiveness Details Estradiol Theophylline Accurbron® Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Estradiol Ticarcillin Decreased contraceptive effectiveness Details Estradiol Tigecycline Tygacil Decreased contraceptive effectiveness Details Estradiol Tirzepatide Mounjaro Reduced absorption of oral contraceptives Details Estradiol Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Estradiol Tocilizumab Actemra Reduced oral contraceptives exposure and reduced efficacy of oral contraceptives Details Estradiol Topiramate Eprontia Reduced hormonal contraceptive exposure, reduced contraceptive efficacy and an increased risk of breakthrough bleeding/contracepti... Details Estradiol Tovorafenib Ojemda Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Estradiol Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Estradiol Troleandomycin Increased contraceptive exposure and an increased risk of intrahepatic cholestasis Details Estradiol Ulipristal Ella Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Estradiol Valproic Acid Depakene® Decreased valproate exposure and increased risk of seizures Details Estradiol Vorasidenib Voranigo Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposur... Details Estradiol Voriconazole Vfend Increased voriconazole exposure, increased ethinyl estradiol and norethindrone exposure Details Estradiol Warfarin Coumadin Altered warfarin exposure, reduced or increased anticoagulant effectiveness and altered INR Details