Estradiol

Name: Estradiol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

216 interactions 765 cited references

Also sold as: Delestrogen

Read the full Estradiol drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Tranexamic Acid Ensitrelvir Cloxacillin Isotretinoin Clozapine

3 Contraindicated 170 Major 31 Moderate 12 Minor

All (216) Contraindicated (3) Major (170) Moderate (31) Minor (12)

Major

Estradiol Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Estradiol Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Estradiol Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Estradiol Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Estradiol Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Estradiol Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Estradiol Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Estradiol Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Estradiol Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details Estradiol Penicillin V Potassium Beepen-VK® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.