Ezetimibe

29 interactions 71 cited references
Also sold as: Zetia Zetia®
About Ezetimibe

Ezetimibe is a cholesterol-lowering medication used to reduce cholesterol and fats in the blood. Read the full Ezetimibe drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gemfibrozil Cyclosporine Cyclosporine Injection Cyclosporine Ophthalmic Danazol Colesevelam
5 Contraindicated 23 Major 1 Moderate
All (29) Contraindicated (5) Major (23) Moderate (1)

Major

Ezetimibe Colchicine Colcrys An increased risk of myopathy or rhabdomyolysis Details Ezetimibe Cholestyramine Resin Locholest® Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Ezetimibe Colesevelam Welchol Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Ezetimibe Colestipol Colestid Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Ezetimibe Aluminum Carbonate, Basic Reduced ezetimibe exposure Details Ezetimibe Aluminum Hydroxide AlternaGEL® Reduced ezetimibe exposure Details Ezetimibe Aluminum Phosphate Reduced ezetimibe exposure Details Ezetimibe Bezafibrate Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Ezetimibe Cholestyramine Prevalite Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Ezetimibe Ciprofibrate Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Ezetimibe Clofibrate Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Ezetimibe Dihydroxyaluminum Aminoacetate Reduced ezetimibe exposure Details Ezetimibe Dihydroxyaluminum Sodium Carbonate Reduced ezetimibe exposure Details Ezetimibe Eltrombopag Alvaiz Increased ezetimibe exposure and an increased risk of ezetimibe-related adverse reactions Details Ezetimibe Fenofibrate Antara Increased ezetimibe exposure and an increased risk of cholelithiasis Details Ezetimibe Fenofibric Acid Fibricor Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Ezetimibe Magaldrate Reduced ezetimibe exposure Details Ezetimibe Magnesium Carbonate Reduced ezetimibe exposure Details Ezetimibe Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Reduced ezetimibe exposure Details Ezetimibe Magnesium Oxide Mag-Ox 400 Reduced ezetimibe exposure Details Ezetimibe Magnesium Peroxide Reduced ezetimibe exposure Details Ezetimibe Magnesium Trisilicate Reduced ezetimibe exposure Details Ezetimibe Simeprevir Olysio® Increased exposure of OATP1B1/3 substrate Details

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