Felodipine and Nilotinib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nilotinib
No brand names on recordFelodipine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of either drug
Interaction Deep Dive
Concurrent administration of nilotinib (a CYP3A4 inhibitor and P-gp substrate) and a P-gp inhibitor and CYP3A4 substrate may increase the exposure of both drugs. Exercise caution if coadministered and dose adjustments of the CYP3A4 substrate may be necessary1.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport of nilotinib; inhibition of CYP3A4-mediated metabolism of substrates by nilotinib
Literature reports
1 report — tap to read
a) During drug interaction studies in patients with chronic myeloid leukemia, coadministration of oral midazolam (a CYP3A4 substrate) and multiple doses of nilotinib resulted in a 2.6-fold increase in midazolam exposure 1.
Common questions
Can I take Felodipine and Nilotinib together?
Increased exposure of either drug Always confirm with your pharmacist or prescriber before making any change.
How serious is the Felodipine and Nilotinib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Felodipine or Nilotinib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TASIGNA(R) oral capsules, nilotinib oral capsules. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2014. DailyMed
Keep reading about Nilotinib
Keep reading about Felodipine
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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