Felodipine

125 interactions 1 explained in plain English 811 cited references
Also sold as: Plendil®
About Felodipine

Felodipine is a calcium channel blocker used to treat high blood pressure. Read the full Felodipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Felodipine Relugolix Orgovyx Increased relugolix exposure Details Felodipine Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Felodipine Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Felodipine Cyclosporine Injection Atopica Increased felodipine exposure, increased risk of felodipine toxicity and increased cycloSPORINE exposure Details Felodipine Cyclosporine Ophthalmic Cequa Increased felodipine exposure, increased risk of felodipine toxicity and increased cycloSPORINE exposure Details Felodipine Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Felodipine Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Felodipine Digoxin Cardoxin® Increased digoxin exposure and an increased risk of bradycardia and advanced complete heart block Details Felodipine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Felodipine Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Felodipine Epirubicin Ellence Increased risk of heart failure Details Felodipine Adagrasib Krazati Increased CYP3A4 substrate exposure Details Felodipine Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Felodipine Atazanavir Reyataz An increased calcium channel blocker exposure Details Felodipine Avacopan Tavneos Increased CYP3A4 substrate exposure Details Felodipine Carbamazepine Carbatrol Reduced felodipine exposure Details Felodipine Ceritinib Zykadia Increased CYP3A substrate exposure Details Felodipine Clarithromycin Biaxin Increased risk of hypotension, acute kidney injury, bradyarrhythmias, lactic acidosis and peripheral edema Details Felodipine Clomipramine Anafranil Increased clomiPRAMINE exposure Details Felodipine Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Felodipine Cobicistat Tybost Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Felodipine Conivaptan Vaprisol Increased CYP3A substrate exposure Details Felodipine Cyclosporine Atopica Increased felodipine exposure, increased risk of felodipine toxicity and increased cycloSPORINE exposure Details Felodipine Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Felodipine Dantrolene Dantrium Severe hyperkalemia with cardiovascular collapse Details Felodipine Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Felodipine Doxorubicin Hydrochloride Liposome Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Felodipine Duvelisib Copiktra Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Felodipine Ensartinib Increased ensartinib exposure Details Felodipine Erythromycin Erythrocin Stearate An increased felodipine exposure, an increased felodipine associated adverse reactions and felodipine toxicity (flushing, edema, t... Details Felodipine Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Felodipine Fexinidazole An increased CYP3A4 substrate exposure Details Felodipine Fluconazole Diflucan Increased felodipine exposure and toxicity (dizziness, hypotension, flushing, headache, peripheral edema) Details Felodipine Fosnetupitant Increased exposure of CYP3A4 substrate Details

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