Drug & supplement interaction

Royal Jelly + Felodipine

Felodipine brand names: Plendil, Renedil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Royal Jelly has a moderate interaction with Felodipine. Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Royal Jelly and Felodipine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Felodipine

Felodipine falls under ANTIHYPERTENSIVE DRUGS — the group Royal Jelly interacts with.

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: felodipine already lowers your blood pressure by relaxing your blood vessels. Royal jelly may have a mild blood-pressure-lowering effect of its own, based mostly on animal studies. So the worry is that the two together could push your pressure down a little too far.

If that happened, you might feel dizzy, lightheaded, tired, or notice your heart racing, especially when you stand up quickly. I want to be honest though: this is a theoretical concern, not something proven in people, so it's on the gentle end of things. Still, if you take felodipine and want to try royal jelly, check in with your pharmacist or doctor first, and keep an eye on your readings at home. And remember, royal jelly can trigger serious allergic reactions in folks with bee allergies or asthma.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  2. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Royal Jelly Also Interacts With Other Medications

Royal Jelly has 173 moderate known drug interactions in our database — the Felodipine one above is one of them. If you take anything else, check it against the full list below.

Moderate 173 No known interaction 2,657 (incl. Felodipine)
Taking anything else?

Check Another of Your Medications Against Royal Jelly

Covers the 2,830 medications we’ve checked against Royal Jelly. Pick one to open its full report.

From our Q&A

Questions About Royal Jelly or Felodipine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Royal Jelly or Felodipine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Felodipine

This page covers Royal Jelly only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Felodipine page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 8 major · 182 moderate · 42 minor.

From our pharmacist’s overview on the Felodipine page

“Felodipine (Plendil) is a blood pressure medicine broken down by the CYP3A4 enzyme, which is why 232 supplements and foods have an interaction on file, eight of them rated major. This list deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Felodipine interaction page

One more smart check

Taking Royal Jelly as Part of a Dietary Supplement Product? Check It for Interactions

We hold 677 real supplement products containing Royal Jelly, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Royal Jelly. Your product may carry other ingredients that interact with Felodipine too, on top of Royal Jelly — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Royal Jelly and Felodipine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Royal Jelly
Top 25%

#299 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Felodipine
Top 25%

#392 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Royal Jelly

What is Royal Jelly?

Royal Jelly
  • Menopausal symptoms
  • Skin health and wound care
  • Immune support
  • General energy and vitality
  • Cholesterol support
  • Eye dryness (eye drops)

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limited for most uses. It is generally well tolerated by most people, but it can cause serious allergic reactions, especially in those allergic to bees or with asthma.

Read the full Royal Jelly monograph & all interactions
Medication

About Felodipine

What Is Felodipine Used For?

Brand names: Plendil, Renedil

Felodipine extended-release tablets are used to treat high blood pressure (hypertension). Lowering blood pressure lowers the risk of strokes and heart attacks.

It can be used alone or with other blood pressure medicines. Many people need more than one drug to reach their blood pressure goal.

See full Felodipine drug information
Keep checking

Other Drugs & Royal Jelly

Browse every other medication we’ve checked against Royal Jelly — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
173Moderate
0Minor
2,656No known interaction
173 Moderate 2,656 No interaction
Moderate

173 interactions

Showing 60 of 173 moderate interactions — see all 173 on the Royal Jelly page.

No interaction 2,656 drugs checked — show the list

We also checked Royal Jelly against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,656 medications checked with no known interaction — see the full Royal Jelly list.

See the full Royal Jelly interactions page
See every supplement checked against Felodipine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Royal Jelly monograph › Uses, safety, and every drug interaction in one place Felodipine supplement interactions › Every supplement checked against Felodipine, ranked by severity Felodipine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Royal Jelly and Felodipine Together: Common Questions

Can you take Royal Jelly with Felodipine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Royal Jelly and Felodipine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Felodipine and Royal Jelly?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.