Paclitaxel and Felodipine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Felodipine
Paclitaxel
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions and toxicity
Interaction Deep Dive
Exert caution when administering PACLitaxel with CYP3A4 substrates12 [and PACLitaxel protein-bound particles for injectable suspension (albumin-bound)] concomitantly with medicines known as CYP3A4 substrates, as concomitant use may result in altered PACLitaxel exposure 3. In vitro studies showed that PACLitaxel was metabolized primarily to 2 minor metabolites, 3'-p-hydroxyPACLitaxel and 6-alpha, 3'-p-dihydroxyPACLitaxel, by CYP3A4. The pharmacokinetics of PACLitaxel may also be altered as a result of interactions in vivo with compounds that are substrates of CYP3A4 13.
Why it happens (mechanism)
Inhibition of CYP3A4-substrates metabolism by PACLitaxel; induction of CYP3A4-substrates metabolism by PACLitaxel
Literature reports
1 report — tap to read
a) In vitro studies showed that PACLitaxel was metabolized primarily to 2 minor metabolites, 3'-p-hydroxyPACLitaxel and 6-alpha, 3'-p-dihydroxyPACLitaxel, by CYP3A4. The pharmacokinetics of PACLitaxel may also be altered as a result of interactions in vivo with compounds that are substrates of CYP3A4 13.
Common questions
Can I take Paclitaxel and Felodipine together?
Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions and toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Paclitaxel and Felodipine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Paclitaxel or Felodipine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: PACLITAXEL intravenous injection, paclitaxel intravenous injection. Fresenius Kabi (per Dailymed), Lake Zurich, IL, 2024. DailyMed
- Product Information: TAXOL(R) IV injection, paclitaxel IV injection. Bristol-Myers Squibb Company, Princeton, NJ, 2011.
- Product Information: PACLITAXEL PROTEIN-BOUND PARTICLES (ALBUMIN-BOUND) intravenous injection lyophilized powder for suspension, paclitaxel protein-bound particles (albumin-bound) intravenous injection lyophilized powder for suspension. Sandoz Inc (per Dailymed), Princeton, NJ, 2024. DailyMed
Keep reading about Felodipine
Keep reading about Paclitaxel
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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