Felodipine

Name: Felodipine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

125 interactions 1 explained in plain English 811 cited references

Also sold as: Plendil®

About Felodipine

Felodipine is a calcium channel blocker used to treat high blood pressure. Read the full Felodipine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Itraconazole Colchicine Levoketoconazole Ensitrelvir Ketoconazole Topical Ketoconazole

6 Contraindicated 83 Major 33 Moderate 3 Minor

All (125) Contraindicated (6) Major (83) Moderate (33) Minor (3)

Major

Felodipine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Felodipine Melphalan Injection Alkeran An increased risk of severe hypotension Details Felodipine Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.