Fenfluramine

19 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Palonosetron Injection Amitriptyline Sertraline Buprenorphine Abiraterone

1 Contraindicated 18 Major

All (19) Contraindicated (1) Major (18)

Contraindicated

Fenfluramine Linezolid Injection Zyvox Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details

Major

Fenfluramine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Sertraline Explained Increased CYP2D6 substrate exposure and an increased risk of serotonin syndrome Details Fenfluramine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Fenfluramine Butorphanol Injection Butorphic An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Dolasetron Anzemet An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Dolasetron Injection Anzemet An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Granisetron Injection Granisol An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Hydromorphone Injection Dilaudid An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Hydromorphone Rectal available generically An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Lithium Carbonate Lithobid An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Morphine Injection Astramorph® PF An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Fenfluramine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.