Fenoprofen and Dicumarol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fenoprofen
Dicumarol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
In patients taking oral anticoagulants, the addition of fenoprofen could prolong the prothrombin time2. Due to the risk of fenoprofen-induced gastric erosions and decreased platelet aggregation 3, be alert for evidence of gastrointestinal bleeding if fenoprofen is used with an oral anticoagulant.
Why it happens (mechanism)
Gastric erosion, inhibition of platelet aggregation
Literature reports
1 report — tap to read
a) In vitro studies have demonstrated that high doses of fenoprofen are capable of displacing warfarin from protein binding sites 1. However, it is unknown whether this occurs to a significant degree with therapeutic doses.
Common questions
Can I take Fenoprofen and Dicumarol together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fenoprofen and Dicumarol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Fenoprofen or Dicumarol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Rubin A, Warrick P, Wolen RL, et al: Physiological disposition of fenoprofen in man. J Pharmacol Exp Ther 1972; 183:449-457.
- Product Information: Nalfon(R), fenoprofen. Dista Products and Eli Lilly and Company, Indianapolis, IN, 1995. DailyMed
- Gilman AG, Rall TW, Nies AS, et alGilman AG, Rall TW, Nies AS, et al (Eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th. Pergaman Press, New York, NY, 1990.
Keep reading about Fenoprofen
Keep reading about Dicumarol
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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