Fenoprofen

290 interactions 351 cited references
Also sold as: Fenopron Nalfon Nalfon®
About Fenoprofen

Fenoprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Fenoprofen is also used to relieve mild to moderate pain from other causes.… Read the full Fenoprofen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Pemetrexed Injection Gossypol
4 Contraindicated 227 Major 59 Moderate
All (290) Contraindicated (4) Major (227) Moderate (59)

Contraindicated

Fenoprofen Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Fenoprofen Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Fenoprofen Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Fenoprofen Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Fenoprofen Amitriptyline Elavil An increased risk of bleeding Details Fenoprofen Sertraline An increased risk of bleeding Details Fenoprofen Apixaban Eliquis An increased risk of bleeding Details Fenoprofen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Fenoprofen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Fenoprofen Azathioprine Azasan An increased risk of hepatotoxicity Details Fenoprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Fenoprofen Anagrelide Agrylin An increased risk of bleeding Details Fenoprofen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Fenoprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Clopidogrel Plavix An increased risk of bleeding Details Fenoprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Fenoprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Fenoprofen Dabigatran Pradaxa® An increased risk of bleeding Details Fenoprofen Dabigatran Etexilate An increased risk of bleeding Details Fenoprofen Dalteparin Injection Fragmin An increased risk of bleeding Details Fenoprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Fenoprofen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Fenoprofen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Fenoprofen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Fenoprofen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Fenoprofen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Fenoprofen Dipyridamole Permole® An increased risk of bleeding Details Fenoprofen Edoxaban Savaysa An increased risk of bleeding Details Fenoprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Fenoprofen Enoxaparin Lovenox An increased risk of bleeding Details Fenoprofen Enoxaparin Injection Lovenox An increased risk of bleeding Details Fenoprofen Epoprostenol Flolan An increased risk of bleeding Details Fenoprofen Etodolac Lodine Increased risk of bleeding Details Fenoprofen Abciximab An increased risk of bleeding Details Fenoprofen Aceclofenac Increased risk of bleeding Details Fenoprofen Acemetacin Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.