Fentanyl
64 interactions 6 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Furosemide Injection
Octreotide Injection
Dexamethasone Injection
Sertraline
Nicardipine
Palonosetron Injection
Major
Fentanyl Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Fentanyl Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Fentanyl Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details Fentanyl Lenacapavir Oral Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details Fentanyl Letermovir Injection Prevymis Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Fentanyl Linezolid Injection Zyvox Potentiation of opioid effects and an increased risk of serotonin syndrome Details Fentanyl Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Fentanyl Metoclopramide Injection Gimoti Increased risk of CNS depression Details Fentanyl Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Fentanyl Midazolam Nasal Spray Nayzilam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Midazolam Injection Nayzilam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Fentanyl Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Nafcillin Injection Unipen® Injection Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Fentanyl Nevirapine Viramune Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Nicardipine Cardene Severe hypotension Details Fentanyl Nifedipine Adalat® An increased risk of severe hypotension and an increased fluid volume requirements Details Fentanyl Octreotide Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Fentanyl Octreotide Injection Bynfezia Increased exposure of CYP3A4 substrates with narrow therapeutic index Details Fentanyl Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.