Fentanyl

64 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fentanyl Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Abametapir Explained Increased exposure of CYP3A4 substrate Details Fentanyl Amitriptyline Elavil Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Fentanyl Sertraline Explained Increased risk of serotonin syndrome Details Fentanyl Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Fentanyl Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Aripiprazole Injection Abilify Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Fentanyl Asenapine Transdermal Patch Secuado Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Fentanyl Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Fentanyl Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Fentanyl Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Fentanyl Clopidogrel Plavix Reduced efficacy of clopidogrel Details Fentanyl Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Cyclosporine Injection Atopica Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Cyclosporine Ophthalmic Cequa Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Dexamethasone Injection Decadron Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Diazepam Rectal Diastat Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Fentanyl Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Fentanyl Dolasetron Anzemet Increased risk of serotonin syndrome Details Fentanyl Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Fentanyl Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Fentanyl Esketamine Nasal Spray Spravato Increased risk of sedation Details Fentanyl Furosemide Injection Disal Reduced diuretic efficacy Details Fentanyl Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Fentanyl Granisetron Injection Granisol Increased risk of serotonin syndrome Details Fentanyl Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Hydroxychloroquine Plaquenil An increased risk of seizures Details Fentanyl Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Ketoconazole Topical Extina® Foam Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Lacosamide Injection Motpoly An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.