Drug & supplement interaction

Shepherd's Purse + Fentanyl

Fentanyl brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Shepherd's Purse has a moderate interaction with Fentanyl. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Shepherd's Purse and Fentanyl

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Fentanyl

Fentanyl falls under CNS DEPRESSANTS — the group Shepherd's Purse interacts with.

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with Shepherd's Purse and Fentanyl. Fentanyl is a strong opioid that calms your brain and nervous system, which is exactly what makes it work for pain but also why it can cause drowsiness, slowed breathing, and a foggy head. Some traditional herbs, including shepherd's purse, are thought to have mild calming or sedative-type effects of their own.

So the concern is simply additive sleepiness. In theory, stacking the two could leave you more drowsy or slow your breathing a bit more than fentanyl alone. I'll be honest though, this is based on how the herb may behave, not on solid human studies, so it's a low-confidence caution. With a medicine as powerful as fentanyl, please run any herbal supplement past your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Shepherd's Purse Also Interacts With Other Medications

Shepherd's Purse has 263 moderate known drug interactions in our database — the Fentanyl one above is one of them. If you take anything else, check it against the full list below.

Moderate 263 No known interaction 2,567 (incl. Fentanyl)
Taking anything else?

Check Another of Your Medications Against Shepherd's Purse

Covers the 2,830 medications we’ve checked against Shepherd's Purse. Pick one to open its full report.

From our Q&A

Questions About Shepherd's Purse or Fentanyl

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Shepherd's Purse or Fentanyl, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fentanyl

This page covers Shepherd's Purse only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fentanyl page lists 226 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 176 moderate · 40 minor.

From our pharmacist’s overview on the Fentanyl page

“There is very little room for error with fentanyl (Duragesic, Sublimaze, Actiq, and other forms), a powerful opioid where a modest rise in blood level or an extra layer of sedation can become dangerous, so this interaction list deserves real respect. Most of the risk falls into two patterns.”

Reviewed by 2 · Jul 18, 2026

Open the Fentanyl interaction page

One more smart check

Taking Shepherd's Purse as Part of a Dietary Supplement Product? Check It for Interactions

We hold 73 real supplement products containing Shepherd's Purse, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Shepherd's Purse. Your product may carry other ingredients that interact with Fentanyl too, on top of Shepherd's Purse — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Shepherd's Purse and Fentanyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Shepherd's Purse
Top half

#671 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fentanyl
Steady interest

#1,745 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Shepherd's Purse

What is Shepherd's Purse?

Shepherd's Purse
  • Heavy or prolonged menstrual bleeding
  • Minor bleeding (nosebleeds, wounds)
  • Mild diuretic
  • Digestive complaints
  • After-childbirth bleeding (traditional)

Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human research is very limited. Because it may affect blood clotting, blood pressure, and the uterus, it should be avoided during pregnancy and used cautiously under professional guidance.

Read the full Shepherd's Purse monograph & all interactions
Medication

About Fentanyl

What Is Fentanyl Used For?

Brand names: Sublimaze, Duragesic, Fentora, Lazanda, Abstral, Subsys

Fentanyl transdermal system is prescribed for severe, persistent pain that cannot be controlled with other pain medicines, including shorter-acting opioids. It is only for people who are already opioid-tolerant — meaning they've been taking a significant daily opioid dose for at least a week.

It is not for short-term pain, post-surgical pain, mild pain, or use on an as-needed basis. Because of serious risks including addiction, overdose, and death, it is reserved for situations where other treatment options have failed or are not appropriate.

See full Fentanyl drug information
Keep checking

Other Drugs & Shepherd's Purse

Browse every other medication we’ve checked against Shepherd's Purse — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
263Moderate
0Minor
2,566No known interaction
263 Moderate 2,566 No interaction
Moderate

263 interactions

Showing 60 of 263 moderate interactions — see all 263 on the Shepherd's Purse page.

No interaction 2,566 drugs checked — show the list

We also checked Shepherd's Purse against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,566 medications checked with no known interaction — see the full Shepherd's Purse list.

See the full Shepherd's Purse interactions page
See every supplement checked against Fentanyl, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Shepherd's Purse monograph › Uses, safety, and every drug interaction in one place Fentanyl supplement interactions › Every supplement checked against Fentanyl, ranked by severity Fentanyl drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Shepherd's Purse and Fentanyl Together: Common Questions

Can you take Shepherd's Purse with Fentanyl?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Shepherd's Purse and Fentanyl interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fentanyl and Shepherd's Purse?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.