Fexinidazole and Nevirapine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nevirapine
Fexinidazole
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of fexinidazole metabolites with possible increased risk of QT prolongation
Interaction Deep Dive
Avoid concomitant use of fexinidazole (a CYP3A4 substrate) with CYP3A4 inducers as increased exposure to the M1 and M2 fexinidazole metabolites may occur, which may increase adverse reactions including QT prolongation1.
Why it happens (mechanism)
Induction of CYP3A4-mediated fexinidazole metabolism
Common questions
Can I take Fexinidazole and Nevirapine together?
Increased exposure of fexinidazole metabolites with possible increased risk of QT prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fexinidazole and Nevirapine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Fexinidazole or Nevirapine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Fexinidazole oral tablets, fexinidazole oral tablets. sanofi-aventis US LLC (per FDA), Bridgewater, NJ, 2021. DailyMed
Keep reading about Nevirapine
Keep reading about Fexinidazole
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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