Nevirapine

163 interactions 1 explained in plain English 537 cited references
Also sold as: Viramune Viramune® Viramune® XR
About Nevirapine

Nevirapine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 15 days of age and older. Nevirapine should not be used to treat healthcare workers or other individuals exposed to HIV infection after contact with HIV-contaminated blood, tissues, or other body… Read the full Nevirapine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nevirapine Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Nevirapine Buprenorphine Belbuca Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Nevirapine Atogepant Qulipta Reduced atogepant exposure Details Nevirapine Azathioprine Azasan An increased risk of hepatotoxicity Details Nevirapine Cariprazine Vraylar Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Nevirapine Amlodipine Amvaz® Reduced amLODIPine exposure Details Nevirapine Avanafil Stendra Decreased avanafil plasma concentrations Details Nevirapine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Nevirapine Cyclophosphamide Cytoxan® Reduced cycloPHOSphamide exposure Details Nevirapine Cyclophosphamide Injection Cytoxan® Injection Reduced cycloPHOSphamide exposure Details Nevirapine Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Nevirapine Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Nevirapine Dexamethasone Injection Decadron Decreased nevirapine plasma concentrations Details Nevirapine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased nevirapine plasma concentrations Details Nevirapine Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Decreased dolutegravir exposure with reduced efficacy Details Nevirapine Doravirine Pifeltro Decreased doravirine plasma concentration and reduced efficacy; increased risk of doravirine resistance Details Nevirapine Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Nevirapine Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nevirapine Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nevirapine Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nevirapine Ethosuximide Zarontin Reduced ethosuximide exposure and reduced nevirapine exposure Details Nevirapine Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Nevirapine Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Nevirapine Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Nevirapine Lenacapavir Injection Sunlenca Reduced lenacapavir exposure and reduced efficacy of lenacapavir Details Nevirapine Lenacapavir Oral Sunlenca Reduced lenacapavir exposure and reduced efficacy of lenacapavir Details Nevirapine Letermovir Injection Prevymis Reduced letermovir exposure and reduced efficacy of letermovir Details Nevirapine Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nevirapine Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nevirapine Lumateperone Caplyta Reduced lumateperone exposure Details Nevirapine Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nevirapine Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nevirapine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Nevirapine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nevirapine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.