Nevirapine and Velpatasvir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nevirapine
Velpatasvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced velpatasvir plasma concentrations
Interaction Deep Dive
Coadministration of velpatasvir and this drug is not recommended as this may significantly decrease velpatasvir plasma concentrations and potentially reduce its therapeutic effects. During pharmacokinetic studies, once daily coadministration of efavirenz/emtricitabine/tenofovir disproxil and sofosbuvir/velpatasvir resulted in a decrease in velpatasvir Cmax and AUC1.
Why it happens (mechanism)
Induction of CYP2B6- and CYP3A4-mediated velpatasvir metabolism
Literature reports
1 report — tap to read
a) During pharmacokinetic studies, once daily coadministration of efavirenz 600 mg/emtricitabine 200 mg/tenofovir 300 mg and sofosbuvir 400 mg/velpatasvir 100 mg resulted in a 47% decrease in velpatasvir Cmax and a 53% decrease in AUC 1.
Common questions
Can I take Nevirapine and Velpatasvir together?
Reduced velpatasvir plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nevirapine and Velpatasvir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Nevirapine or Velpatasvir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VOSEVI(TM) oral tablets, sofosbuvir velpatasvir voxilaprevir oral tablets. Gilead Sciences Inc (per manufacturer), Foster City, CA, 2017. DailyMed
Keep reading about Nevirapine
Keep reading about Velpatasvir
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