Nevirapine and Delavirdine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Delavirdine
Nevirapine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered exposure of delavirdine, nevirapine or both
Interaction Deep Dive
Concomitant use of non-nucleoside reverse transcriptase inhibitors, such as delavirdine and nevirapine, is not recommended because the combination has not been shown to be beneficial. Nevirapine is a CYP3A and a CYP2B6 substrate and inducer12, while delavirdine is a CYP3A substrate, has shown inhibition of CYP3A activity and its own metabolism in vitro and in vivo 3.
Why it happens (mechanism)
Unclear
Common questions
Can I take Nevirapine and Delavirdine together?
Altered exposure of delavirdine, nevirapine or both Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nevirapine and Delavirdine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Nevirapine or Delavirdine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: VIRAMUNE XR(R) oral extended release tablets, nevirapine oral extended release tablets. Boehringer Ingelheim Pharmaceuticals, Inc. (per FDA), Ridgefield, CT, 2014. DailyMed
- Product Information: VIRAMUNE(R) oral tablets, oral suspension, nevirapine oral tablets, oral suspension. Boehringer Ingelheim Pharmaceuticals, Inc. (per FDA), Ridgefield, CT, 2014. DailyMed
- Product Information: RESCRIPTOR(R) oral tablets, delavirdine mesylate oral tablets. ViiV Healthcare (per FDA), Research Triangle Park, NC, 2012.
Keep reading about Delavirdine
Keep reading about Nevirapine
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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